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Department of Mathematics,
University of California San Diego

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Math 218: Seminars on Mathematics for Complex Biological Systems

Alex Klotz

CSU Long Beach

Mathematical Investigations of Kinetoplast DNA

Abstract:

Kinetoplast DNA, often described as molecular chainmail, is found in the mitochondria of trypanosome parasites and consists of thousands of topologically interlocked circular molecules. In addition to its biological role in gene editing, it has been explored recently as a model system for materials science, due to its unique topological connectivity and its two-dimensional structure. In this talk, I will discuss some mathematical investigations that have emerged out of materials-based research of kinetoplast DNA, including the relationship between the link topology of the network and the Gaussian curvature of chainmail membranes, as well as methods to detect Borromean linking within densely linked networks.

April 3, 2025

2:00 PM

APM 7321

Research Areas

Mathematical Biology

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